Head of Strategy, Portfolio & Pipeline Operations, Internal Medicine

Pfizer is seeking a senior, enterprise leader to serve as Head of Strategy, Portfolio & Pipeline Operations for Internal Medicine, reporting to the Chief Internal Medicine Officer, serving as a key member of the Internal Medicine Leadership Team. This role is responsible for leading Internal Medicine strategy, portfolio management, and operational execution, partnering closely with the Chief Internal Medicine Officer to define and communicate a unified strategy and build a high-value, practice-changing portfolio across development and commercialization. Operating at the intersection of R&D, commercial, and enterprise functions, this leader will establish and drive a rigorous decision-making framework for pipeline management, ensuring that investments are prioritized effectively and that the portfolio evolves to maximize value. The role also carries end-to-end accountability for advancing the pipeline with urgency, ensuring programs are executed efficiently, risks are anticipated early, and cross-functional teams are mobilized quickly to address critical inflection points. Beyond portfolio leadership, this individual will serve as a core thought partner to the Chief Internal Medicine Officer and Internal Medicine Leadership Team. This includes helping to shape enterprise prioritization and resourcing decisions, championing Internal Medicine across the organization, and advancing the integration of data, digital, and AI capabilities throughout the category. Success in this role will require an agile and highly proactive leader who can seamlessly move between long-term strategy and real-time execution—anticipating issues before they fully emerge and rapidly assembling the right cross-functional expertise and resources to address them. This leader will play a critical role in ensuring the organization is both strategically aligned and operationally responsive in a dynamic environment. Drive end-to-end strategy across the major pillars of Internal Medicine—obesity/metabolic, migraine/pain, and cardiovascular—building sustainable leadership from target identification through market presence Transform Internal Medicine R&D into an AI-native organization, working with colleagues across functions—including Digital—to embed AI in how the pipeline is discovered, developed, and advanced Key Responsibilities: Strategy Development & Category Leadership Partner with the Chief Internal Medicine Officer to define, refine, and communicate a cohesive Internal Medicine strategy across internal and external stakeholders Lead periodic strategy development and review processes, including preparation for and management of governance forums Maintain a comprehensive, forward-looking view of the Internal Medicine landscape, including unmet need, value pools, competitive dynamics, clinical pipelines, and emerging science and modalities Identify strategic options to build leadership in priority disease areas across short-term and long-term horizons Act as a strategic advisor to the Internal Medicine Leadership Team, supporting decisions across portfolio, operations, resourcing, and long-term category positioning Portfolio Management & Decision Excellence Lead global portfolio management across drug and non-drug investments, including data and AI initiatives Establish consistent, objective processes and standards for evaluating business cases and investment decisions Enable effective trade-offs and re-prioritization as data evolves or plans shift, ensuring continuous optimization of the portfolio Conduct regular end-to-end portfolio reviews and health checks to assess performance against defined thresholds and goals Deliver portfolio analytics and insights to enterprise leadership and external stakeholders through dashboards and reporting Manage governance processes for pipeline and portfolio decision-making within Internal Medicine Lead improvements in cross-functional decision-making framework with Clinical Development, Translational Medicine,