Director, Biotherapeutic Production Technologies

Generate:Biomedicines is seeking an experienced and innovation-minded Director, Biotherapeutic Production Technologies, to define the strategy and lead the team responsible for protein expression, purification, and fit-for-purpose characterization in support of discovery and early development.

This leader will be accountable for delivering high-quality protein material at the scale, speed, and scientific rigor required to support critical program decisions. The Director will advance the technologies, workflows, external partnerships, and team capabilities that enable programs to move from exploratory protein science toward development with confidence.

The role will oversee protein production across multiple expression platforms, including transient mammalian, stable CHO, and cell-free systems. The team’s downstream scope includes affinity capture, Protein A, size-exclusion chromatography, ion exchange, and other polishing methods used to generate research- and in vivo–enabling material.

The Director will balance reliable operational execution with scientific and technology innovation. This person will establish fit-for-purpose standards for material quality, reproducibility, data integrity, and decision-making while serving as a senior technical leader across protein production technologies.

The successful candidate will bring broad expertise across upstream expression and downstream purification, with particular strength in stable cell line technologies, vector and construct design, multi-gene expression, and the production of diverse or complex therapeutic protein modalities. This leader will partner closely with Discovery, Molecular Characterization, CMC/Tech Ops, data and automation teams, and external CRO and CDMO partners.

We are also seeking a leader who is excited to apply AI/ML-enabled and agentic tools, automation, and structured data workflows to improve speed, quality, scalability, and organizational learning across protein production.

This role will lead teams at both our Somerville, MA and Andover, MA locations.

• Define and execute the functional strategy and technology roadmap for Biotherapeutic Production Technologies, aligning priorities with discovery portfolio, platform, and early development needs.

• Translate functional strategy into clear scientific objectives, operating plans, technology investments, and measurable outcomes. Communicate progress, risks, resource needs, and tradeoffs to senior and executive stakeholders.

• Lead portfolio-level planning and prioritization across internal and outsourced protein-production activities, balancing program delivery, platform advancement, capacity, timelines, and external spend.

• Oversee protein expression across transient mammalian, stable CHO, and cell-free production systems. Establish scientific and operational standards that support robust, scalable, and reproducible execution.

• Drive innovation in stable-expression technologies, including construct and vector design, stable pool and clone generation, multi-gene expression strategies, and emerging landing-pad or targeted-integration approaches.

• Establish and oversee purification strategies spanning affinity capture, Protein A, size-exclusion chromatography, ion exchange, and other polishing methods used to generate high-quality research- and in vivo–enabling material.

• Establish fit-for-purpose quality standards and characterization strategies for purity, aggregation, concentration, identity, oligomeric state, stability, and other attributes relevant to intended material use.

• Serve as a senior technical decision-maker for highly complex expression, purification, and protein-quality challenges. Integrate data across workflows, evaluate scientific and operational risk, and determine