Senior Director, ECD Product Strategy

POSITION SUMMARY: As a market leader in cfDNA-based diagnostics, we are expanding our Early Cancer Detection (ECD) portfolio to deliver transformative clinical impact at scale. The Senior Director, ECD Product Strategy will lead the strategy, development, and lifecycle management of a portfolio of ECD products, from concept through launch, growth, and optimization. This role is accountable for defining product vision and strategy, translating unmet clinical and customer needs into differentiated products, and driving execution through strong cross-functional leadership. The Senior Director will build and manage a high-performing product management team and partner closely with R&D, clinical, regulatory, commercial, medical affairs, and operations to ensure successful delivery of business and patient outcomes. POSITION LOCATION: This position can be out of our San Carlos, CA office or Remote, USA. PRIMARY RESPONSIBILITIES: Product Strategy & Portfolio Leadership

Own the product vision, strategy, and roadmap for the Early Cancer Detection portfolio, aligned with corporate strategy and long-term growth objectives Lead annual and multi-year strategic planning for ECD products, including investment prioritization, sequencing, and resource allocation Identify, size, and segment new market opportunities using top-down and bottom-up analyses, incorporating clinical, commercial, and customer insights Define clear value propositions and differentiation strategies based on competitive intelligence, customer needs, and evolving standards of care

Product Lifecycle Management

Lead products across the full lifecycle, from concept and feasibility through development, launch, post-launch optimization, and eventual sunset Drive definition of product requirements, success metrics, and launch readiness in partnership with cross-functional teams Guide trade-off decisions across performance, features, timelines, and investment, particularly in technically complex genomic and algorithm-driven products

Customer & Market Insights

Lead qualitative and quantitative customer research with clinicians, health systems, payers, partners, and internal stakeholders Translate insights into clear product requirements, roadmap decisions, and business cases Monitor competitive landscape, emerging technologies, and regulatory or reimbursement changes impacting early cancer detection

Financial & Business Planning

Build and oversee robust business cases, including revenue forecasts, unit economics, ROI, and NPV analyses for new and existing products Pressure-test assumptions, evaluate sensitivities, and make data-driven investment recommendations Partner with finance and commercial leadership to align product strategy with financial objectives

People & Cross-Functional Leadership

Lead, and develop a team of Product Managers supporting innovation and lifecycle initiatives within Early Cancer Detection Establish and scale product management best practices, processes, and metrics Act as a senior product leader and influencer across R&D, clinical, regulatory, medical affairs, commercial, and executive leadership Clearly communicate product vision, strategy, and priorities to align stakeholders and inspire teams

Bachelor’s degree required; advanced degree (PhD, MD, or MBA) strongly preferred 10+ years of experience in product management, product strategy, consulting, or related roles within diagnostics, biotechnology,