Senior Research Associate, Functional Genomics

The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.

While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:

• Funding: Arc fully funds Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.

• Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize, and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.

• Support: Arc aims to provide first-class support—operationally, financially, and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.

• Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.

Arc has scaled to nearly 300 people to date. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.

The Mammalian Models Technology Center is seeking a motivated Senior Research Associate (SRA) to join the In Vivo Functional Genomics Team.

In this position, you will contribute to execute large-scale in vivo perturbation screens aimed at mapping the genetic circuits that govern immune functions across different tissues. This work is integral to two key initiatives: the Virtual Cell Initiative, which seeks to build the first foundation model for accurate predictions about cell states, and the Alzheimer’s Disease Initiative, which applies these methods to find cures for Alzheimer's.

This position offers an exceptional opportunity to apply and develop cutting-edge technologies to unveil the molecular principles that govern cellular fates. You will join a multidisciplinary team working at the crossroads of Immunology, Neuroscience, CRISPR technologies, Multi-omics and Computational biology. A key aspect of this role is the opportunity to collaborate closely with pioneering labs that have developed the foundational toolbox for functional genomics screens, such as CRISPR nucleases, CRISPRi, CRISPRoff, CRISPRa, and serine or bridge recombinases.

• You love science and learning. Whether it’s gaining knowledge in new fields of scientific research or learning a new lab technique, you never stop being curious and routinely enjoy stepping out of your comfort zone to learn new things.

• You can work fast and are detail-oriented. You are careful and diligent about good documentation practices and keeping things organized while moving at a rapid pace.

• You love to collaborate and help others. Science is a team effort, and you pride yourself in taking the initiative to help.

• You are a problem solver. It's common in science to come across issues you need to troubleshoot, and you pride yourself in your ability to independently and collaboratively troubleshoot complex problems in the