Senior Scientist, II Biologics & Genetic Medicine - LCMS Characterization & Bioanalysis

About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

AbbVie is seeking a highly motivated and experienced scientist to join our Quantitative, Translational & ADME Sciences (QTAS) team in North Chicago. The ideal candidate will have strong expertise in developing and implementing LC/MS-based bioanalysis and in vitro characterization assays for novel biologics. This role will support sample preparation, method development, bioanalytical assay operations, data analysis, report generation, and data presentation. In this laboratory-based role, the scientist will help implement innovative quantitative and qualitative approaches to advance stability characterization of novel biologic entities using both conventional and more complex in vitro models. The position will also involve scientific leadership in the conduct of in vitro serum aggregation and stability assays for novel biologics. In addition, the successful candidate will qualify, validate, and evaluate new technologies while executing operational activities that support AbbVie’s growing novel biologics and genetic medicine pipeline.

Operate and maintain LC/MS instruments to generate high-quality experimental data. Perform affinity purification of biotherapeutics, including but not limited to monoclonal and multispecific antibodies, antibody-drug conjugates, antibody-siRNA conjugates, and tLNPs. Analyze data and maintain detailed, accurate, and comprehensive study documentation in electronic laboratory notebooks. Communicate data interpretation internally and externally as needed. Support method development and assay optimization for quantitative bioanalysis and in vivo stability assessment of novel biologic entities to ensure laboratory capacity and data quality. Evaluate novel in vitro tools and methods, and apply established concepts to assess serum aggregation and stability of biologics and genetic medicine modalities. Serve as a characterization liaison for novel biologic entities within QTAS, partnering with QTAS representatives, HT-ABBA, Discovery BGM, ADC Discovery, and Conjugation teams to coordinate submissions, allocate requests, and review in vitro stability data. Stay current with emerging literature and scientific advances in biologics in vitro characterization and bioanalysis. Leverage AI-enabled tools and data-driven approaches to predict and deepen understanding of the biophysical and stability properties of biologics, supporting more efficient characterization and informed decision-making. Mentor/ supervise team of 2-3 scientist/senior scientist Qualifications PhD in Biological Sciences, Pharmaceutical Sciences, Chemistry, or a related field with 4+ years of relevant bioanalytical pharma/biotech industry experience; or a Bachelor’s or Master’s degree with more than 10 years of experience in biologics characterization, bioanalysis, and DMPK projects through academic or industry work. Demonstrated understanding of the biophysical and biochemical properties of biologics, including aggregation, post-translational modifications, and stability. In-depth understanding of LC-MS methodology, with a focus on protein mass spectrometry; hands-on experience with a wide range of mass spectrometers, including QQQ, TOF, and Orbitrap platforms, is highly desired. Deep understanding of biologics and ADC in vitro characterization, including serum